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Publications and Research

 

Publications

Open for Recruitment

 Presentations

  • The following presentations are available by request via the contact us page.

  • Autologous adipose-derived mesenchymal stem cell therapy in the treatment of knee chondropathology - Sports Medicine Australia National Conference -2019

  • Evaluation of intra-articular adipose derived mesenchymal stem cell in the treatment of symptomatic knee osteoarthritis - A Randomised Controlled Trial - International Society Cell and Gene Therapy Annual Scientific Conference -2019

  • Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis - a randomised controlled trial. - Australasian College of Sport and Exercise Physicians Annual Scientific Conference -2019

  • An update on injectable therapies - with a focus in orthobiologicals - Australasian Musculoskeletal Imaging Group -2019

  • The evaluation of intra-articular adipose derived mesenchymal stem cell therapy in combination with arthroscopic abrasion arthroplasty - a pilot study - International Society of Stem Cell Research Annual Scientific Conference - 2018

  • Evaluation of intra-articular adipose derived mesenchymal stem cell in the treatment of symptomatic knee osteoarthritis - A Randomised Controlled Trial - International Society of Stem Cell Research Annual Scientific Conference - 2018

  • The use of mesenchymal stem cells in knee osteoarthritis - International Society Cell Therapy ANZ Regional Meeting - 2016

  • The use of mesenchymal stem cells in knee osteoarthritis - Sports Medicine Australia National Conference - 2016

  • Use of Mesenchymal Stem Cells in degenerative joint conditions - initial outcome data - Australian Podiatry Association State Conference -2016

  • The Knee - anatomy, history and examination - Australasian College of Sport and Exercise Physicians GP Symposium - 2015

  • The use of mesenchymal stem cells in knee osteoarthritis : initial outcome results - Australasian College of Sport and Exercise Physicians Annual Scientific Conference - 2015

  • The use of mesenchymal stem cells in degenerative knee conditions. - Ossur International Conference : Iceland 2015

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Osteoarthritis

 
 

Osteoarthritis is a major cause of disability and chronic pain in Australia; more than 3.95 million Australians suffer from arthritis. Up to two-thirds of people with osteoarthritis are of working age. Osteoarthritis is characterized by pain, loss of joint space, and joint deformity. Osteoarthritis is a progressive condition, which means it continually worsens. Traditional treatments concentrate only on pain relief/analgesia. We want to change this and the only way to do it is through ethics-approved research and publications.

The Melbourne Stem Cell Centre Research team is working on exciting and important initiatives in collaboration with Charles Sturt University. Focusing on emerging treatments for osteoarthritis, particularly those that aim to alleviate pain, enhance function, and modify the disease.

Gaining ethics approvals is indeed a crucial part of this process. It ensures that the research is conducted in a way that respects the rights and welfare of participants and adheres to high ethical standards. This step is vital for the credibility and acceptance of the research outcomes.

 
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Current Research Studies

Evaluation of adipose derived mesenchymal stem cells for the treatment of arthritis - Knee

The purpose of this study is to formally follow up and record the safety and effectiveness of autologous (your own) stem cell injections in the treatment of knee arthritis. A secondary objective is to determine whether stem cell therapy offers disease modifying potential and therefore whether it can limit, prevent or possibly reverse progression of arthritis. This study is currently open for recruitment but at this stage entry into the study is patient funded.

Key inclusion criteria

  1. Radiological diagnosis of arthritis using the American College of Rheumatology criteria

  2. Primary arthritis treatment already undertaken. Autologous MSC is an invasive treatment and guidelines recommend trialling conservative measures as the first line of treatment in osteoarthritis

  3. Sufficient English skills to complete the questionnaires required for the study, as well as to understand the instructions given by the study doctors.

  4. Be 18 years of age or older.

 Key exclusion criteria

  1. Age <18yrs.

  2. Pregnancy or Breastfeeding.

  3. Have other causes of their symptoms suspected to be due to serious pathology such as tumour or referral from the spine. These conditions are not under investigation within the current project.

  4. Current cancer.

  5. History of significant organ impairment/failure.

  6. History of allergy to any substances used within the treatments.

  7. Bovine allergy

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Evaluation of adipose derived mesenchymal stem cells for the treatment of arthritis - Hip

The purpose of this study is to formally follow up and record the safety and effectiveness of autologous (your own) stem cell injections in the treatment of hip arthritis. A secondary objective is to determine whether stem cell therapy offers disease modifying potential and therefore whether it can limit, prevent or possibly reverse progression of arthritis. This study is currently open for recruitment but at this stage entry into the study is patient funded.

Key inclusion criteria

  1. Radiological diagnosis of arthritis using the American College of Rheumatology criteria

  2. Primary arthritis treatment already undertaken. Autologous MSC is an invasive treatment and guidelines recommend trialling conservative measures as the first line of treatment in osteoarthritis

  3. Sufficient English skills to complete the questionnaires required for the study, as well as to understand the instructions given by the study doctors.

  4. Be 18 years of age or older.

 Key exclusion criteria

  1. Age <18yrs.

  2. Pregnancy or Breastfeeding.

  3. Have other causes of their symptoms suspected to be due to serious pathology such as tumour or referral from the spine. These conditions are not under investigation within the current project.

  4. Current cancer.

  5. History of significant organ impairment/failure.

  6. History of allergy to any substances used within the treatments.

  7. Bovine allergy

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Evaluation of adipose derived mesenchymal stem cells for the treatment of arthritis - Foot & Ankle

 The purpose of this study is to formally follow up and record the safety and effectiveness of autologous (your own) stem cell injections in the treatment of joints in the foot and anlke that have arthritis. A secondary objective is to determine whether stem cell therapy offers disease modifying potential and therefore whether it can limit, prevent or possibly reverse progression of arthritis. This study is currently open for recruitment but at this stage entry into the study is patient funded.

Key inclusion criteria

  1. Radiological diagnosis of arthritis using the American College of Rheumatology criteria

  2. Primary arthritis treatment already undertaken. Autologous MSC is an invasive treatment and guidelines recommend trialling conservative measures as the first line of treatment in osteoarthritis

  3. Sufficient English skills to complete the questionnaires required for the study, as well as to understand the instructions given by the study doctors.

  4. Be 18 years of age or older.

 Key exclusion criteria

  1. Age <18yrs.

  2. Pregnancy or Breastfeeding.

  3. Have other causes of their symptoms suspected to be due to serious pathology such as tumour or referral from the spine. These conditions are not under investigation within the current project.

  4. Current cancer.

  5. History of significant organ impairment/failure.

  6. History of allergy to any substances used within the treatments.

  7. Bovine allergy

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Evaluation of adipose derived mesenchymal stem cells for the treatment of arthritis - Upper Limb

The purpose of this study is to formally follow up and record the safety and effectiveness of autologous (your own) stem cell injections in the treatment of upper limb arthritis. A secondary objective is to determine whether stem cell therapy offers disease modifying potential and therefore whether it can limit, prevent or possibly reverse progression of arthritis. This study is currently open for recruitment but at this stage entry into the study is patient funded.

Key inclusion criteria

  1. Radiological diagnosis of arthritis using the American College of Rheumatology criteria

  2. Primary arthritis treatment already undertaken. Autologous MSC is an invasive treatment and guidelines recommend trialling conservative measures as the first line of treatment in osteoarthritis

  3. Sufficient English skills to complete the questionnaires required for the study, as well as to understand the instructions given by the study doctors.

  4. Be 18 years of age or older.

 Key exclusion criteria

  1. Age <18yrs.

  2. Pregnancy or Breastfeeding.

  3. Have other causes of their symptoms suspected to be due to serious pathology such as tumour or referral from the spine. These conditions are not under investigation within the current project.

  4. Current cancer.

  5. History of significant organ impairment/failure.

  6. History of allergy to any substances used within the treatments.

  7. Bovine allergy

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